How the kidney filters about 180 litres a day and keeps all but 1.5 litres. Filtration, reabsorption and secretion in each part of the nephron, the counter current that makes urine concentrated, and the hormones that tune the kidney: ADH, renin and angiotensin, aldosterone and ANF.
3 lessons, about 1 h 30 min3 simulations11 problems3 practice questionsPython in every lesson
Urine forms in three steps. The glomerulus filters the plasma, the tubule takes back almost everything that the body needs, and the tubule adds a few more wastes. This lesson gives the numbers of the filtration and explains what each part of the tubule does.
The human kidney can make urine about four times as concentrated as the filtrate. It does so because the loop of Henle and the vasa recta make the fluid of the medulla saltier with depth, from 300 to about 1200 mOsmol per litre. This lesson explains the counter current mechanism step by step.
The kidney does not work alone. The hypothalamus, the juxtaglomerular apparatus and the heart control it, by ADH, by the renin-angiotensin mechanism and by ANF. This lesson explains the three controls, and what goes wrong in diabetes insipidus.
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