How does carbon dioxide travel back from the tissues? You follow the bicarbonate pathway and the chloride shift. You find the centres in the brain that set the rhythm of breathing. You also learn what goes wrong in asthma, emphysema and the dust diseases of workers.
3 lessons, about 1 h 20 min3 simulations10 problems3 practice questionsPython in every lesson
Carbon dioxide travels in the blood in three forms: about 70 per cent as bicarbonate, 20 to 25 per cent bound to haemoglobin as carbamino-haemoglobin, and about 7 per cent dissolved in plasma. The enzyme carbonic anhydrase of the red blood cells works in both directions, forward in the tissues and backward in the alveoli. Each 100 mL of deoxygenated blood delivers about 4 mL of carbon dioxide to the alveoli.
The respiratory rhythm centre in the medulla is mainly responsible for the rhythm of breathing. The pneumotaxic centre in the pons can shorten inspiration, and the chemosensitive area next to the rhythm centre reacts to carbon dioxide and hydrogen ions. Receptors in the aortic arch and the carotid artery also send signals. Oxygen has only an insignificant role in the regulation.
Asthma is a difficulty in breathing with wheezing, caused by inflammation of the bronchi and the bronchioles. Emphysema is a chronic disorder in which the walls of the alveoli are damaged, so the respiratory surface becomes smaller, and smoking is a major cause. Dust in some industries can cause inflammation and fibrosis of the lungs, and workers need masks.
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