Try it on paper first. A hint, the key idea and the worked solution are here when you need them.
The thyroid of a teaching model gives, for an iodine supply of (as a share of the normal supply), a thyroid hormone level and a TSH level . Both levels are shares of the normal level, and gives and TSH .
The thyroid makes T4 and T3, which need iodine. TSH controls the thyroid, and the thyroid hormones act back on the hypothalamus and pituitary by negative feedback. Too little iodine gives a goitre with a high TSH. Too much thyroid hormone, as in Graves' disease, gives a high metabolic rate.
Have you tried it?
Work it out on paper first. It is fine to get stuck or make a mistake: that is how we learn. When you are ready, go through the solution one step at a time, and check each step against your own.
Given. and TSH .
Plan. Find first, then TSH.
Step 1. . . . , which is of normal.
Step 2. TSH. , which is of normal.
Step 3. . . . , which is of normal.
Answer: ; ; .
Check. The hormone falls and TSH rises, which is what the feedback loop does when iodine is short.
Watch out. This is a teaching model of a feedback loop. It is not a measurement of a real person.
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