For each hormone, give the chemical group and say whether its receptor is in the cell membrane or…
Contributed by StemPy LabTry it on paper first. A hint, the key idea and the worked solution are here when you need them.
For each hormone, give the chemical group and say whether its receptor is in the cell membrane or inside the cell.
- Insulin.
- Cortisol.
- Adrenaline.
- Thyroxine.
- Glucagon.
- Testosterone.
Need a reminder? The key ideaShow
A hormone acts only through a specific receptor in the target tissue. Peptide hormones and adrenaline bind to receptors in the membrane and work through second messengers such as cyclic AMP. Steroid hormones and thyroid hormones pass into the cell, bind to receptors inside, and act on the genes. The fraction of receptors occupied is hormone divided by (Kd plus hormone).
The worked solution
Have you tried it?
Work it out on paper first. It is fine to get stuck or make a mistake: that is how we learn. When you are ready, go through the solution one step at a time, and check each step against your own.
Step 1. (a) Peptide hormone. Receptor in the cell membrane.
Step 2. (b) Steroid. Receptor inside the cell.
Step 3. (c) Amino acid derivative. Receptor in the cell membrane.
Step 4. (d) Iodothyronine. Receptor inside the cell.
Step 5. (e) Peptide hormone. Receptor in the cell membrane.
Step 6. (f) Steroid. Receptor inside the cell.
Answer: membrane receptors for insulin, adrenaline and glucagon; intracellular receptors for cortisol, thyroxine and testosterone.
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