Try it on paper first. A hint, the key idea and the worked solution are here when you need them.
A single human cell has a DNA thread about long in all, shared among its chromosomes ( pairs). Take this value for a body cell in G1 phase.
Have you tried it?
Work it out on paper first. It is fine to get stuck or make a mistake: that is how we learn. When you are ready, go through the solution one step at a time, and check each step against your own.
(a) Per chromosome. . A thread about this long is packed into a nucleus only a few micrometres across.
(b) At metaphase. During S phase the amount of DNA per cell doubles, from 2C to 4C. So the cell now holds of DNA. The number of chromosomes stays .
(c) Chromatids and kinetochores. Each metaphase chromosome is made of two sister chromatids held together at the centromere: chromatids. Kinetochores are disc-shaped structures on the sides of the centromere, one for each chromatid: one chromatid is joined by its kinetochore to spindle fibres from one pole, and its sister by its own kinetochore to the opposite pole. So there are kinetochores.
(d) After cytokinesis. At anaphase the sister chromatids separate and go to opposite poles, so each daughter cell gets one chromatid of every chromosome: chromosomes and of DNA, as in the parent cell at G1.
Answer: (a) . (b) . (c) chromatids and kinetochores. (d) .
Check. The two daughter cells together hold , all the DNA of the metaphase cell. Nothing is lost or gained in mitosis.
Watch out. Doubling the DNA does not double the chromosome number. A metaphase cell has chromosomes but chromatids.
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